目的 研究微量营养素对人类免疫缺陷病毒（HIV）感染者体内免疫状态的影响。方法 将102名HIV感染者分为对照组和试验组,分别给予安慰剂和复合微量营养素片,在研究开始及结束时分别进行体格测量和免疫状态测定。结果 两组受试者在年龄、身高、体重和男女性别比方面差异没有统计学意义(P均＞0.05)。研究前两组受试者体内的CD3+、CD4+、CD8+ T淋巴细胞水平和IgA、IgG、IgM、C3水平差异没有统计学意义(P均＞0.05);研究后试验组CD3+、CD4+、CD8+ T淋巴细胞水平和IgA、IgG、IgM、C3水平均明显高于研究前和对照组(P均＜0.05),对照组与研究前差异无统计学意义(P均＞0.05)。结论 补充微量营养素能改善HIV感染者的细胞和体液免疫功能。
Objective To summarize the clinical features and analyze the serologic test results of latent syphilis. Methods The clinical data of 601 patients with latent syphilis who were treated in the sexually transmitted disease centre of Peking Union Medical College Hospital between January 2001 and November 2007 were retrospectively analyzed. Results Of the 601 cases of latent syphilis,there were 174 cases of early latent syphilis(EL),170 cases of late latent syphilis(LL),and 257 cases of unknown latent syphilis. Male to female ratio was 0.74:1（256 males and 345 females,respectively). Patients aged 20-39 years accounted for the largest proportion. Non-marital sexual intercourse was the main route of infection. Forty-six patients (7.65%) were co-infected with other sexually transmitted diseases. A total of 251 cases of latent syphilis (41.76%) were confirmed when the patients were receiving tests for other sexually transmitted diseases or suspected sexually transmitted diseases. Of the 601 patients with EL,LL and unknown latency,the proportion of serum rapid plasma reagin(RPR) titers higher than or equal to 8 were 72.99% (127/174),52.94% (90/170),and 60.31%(155/257),respectively. Compared with the early syphilis,serological negative conversion rate was significantly lower after treatment for l2 months in the early latent syphilis patients (P=0.044). Conclusion Education and awareness raising on syphilis should be strengthened to lower the prevalence of latent syphilis.
[1] Benedet JL, Bender H, Jones H 3rd, et al. FIGO staging classifications and clinical practice guidelines in the management of gynecologic cancersFIGO Committee on Gynecologic Oncology[J].Int J Gynaecol Obstet.2000,70(2):209-262
[2] Oehler MK, Wain GV, Brand A. Gynaecological malignancies in pregnancy: a review[J].Aust N Z J Obstet Gynaecol.2003, 43(6):414-420
[3] Sayedur Rahman M, Al-Sibai MH, Rahman J, et al. Ovarian carcinoma associated with pregnancy. A review of9 cases[J]. Acta Obstet Gynecol Scand, 2002, 81(3):260-264.
[4] Machado F, Vegas C, Leon J, et al. Ovarian cancer during pregnancy: analysis of 15 cases[J].Gynecol Oncol.2007, 105(2):446-450
[5] 付晨薇, 杨佳欣, 刘俊涛, 等. 剖宫产术中附件包块手术病例分析[J]. 中华围产医学杂志, 2007, 10(5):336-338.
[6] Behtash N, Karimi Zarchi M, Modares Gilani M, et al. Ovarian carcinoma associated with pregnancy: a clinicopathologic analysis of 23 cases and review of the literature[J].BMC Pregnancy Childbirth.2008, 8:3-
[7] Palmer J, Vatish M, Tidy J. Epithelial ovarian cancer in pregnancy: a review of the literature[J].BJOG.2009, 116(4):480-491
[8] Leiserowitz GS, Xing G, Cress R, et al. Adnexal masses in pregnancy: how often are they malignant[J].Gynecol Oncol.2006, 101(2):315-321
[9] Modares Gilani M, Karimi Zarchi M, Behtash N, et al. Preservation of pregnancy in a patient with advanced ovarian caner at 20 weeks of gestation: case report and literature review[J].Int J Gynecol Cancer.2007, 17(5):1140-1143
[10] Zemlickis D, Lishner M, Degendorfer P, et al. Fetal outcome after in utero exposure to cancer chemotherapy[J].Arch Intern Med.1992, 152(3):573-576
[11] Kwon YS, Mok JE, Lim KT, et al. Ovarian cancer during pregnancy: clinical and pregnancy outcome[J].J Korean Med Sci.2010, 25(2):230-234
[12] Jameel A, Jamil SN. Safety of cytotoxic chemotherapy during pregnancy[J]. J pak Med Assoc, 2007, 57(9):449-452.
[13] Ishioka S, Hayashi T, Endo T, et al. Advanced epithelial ovarian carcinoma during pregnancy[J].Int J Clin Oncol.2007, 12(2):375-378
