Using the 2020 Demographic and Employment data from the Poverty Reduction Bureau of Fengning County, we adopted the perspective of outflow place to analyze the factors at the family level that might influence the destination choices of the relative poverty labor. We founded that: firstly, nearly sixty percent of them regarded migration as a family livelihood strategy. They preferred to work in other counties or cities within the province. Secondly, family structures and care burden were key influence factors of participants’destination choices. Specifically speaking, when their children were in primary and secondary stages, the relative poverty labor force would have to choose to work within the province to accompany studying. On the contrary, with the total number of households’labor force and the care burden for the elder, the relative poverty labor was likely to choose to work outside. Thirdly, the relative deprivation showed little influence on their destination choices. This paper helps to understand destination choices of relative poverty labor, and the influential mechanisms of family factors on their choices. Furthermore, there are certain implications both for improving Employment Social Policy and developing migration research.